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Manchester United exited the Champions League in spectacular style as Sevilla secured an extraordinary 2-1 win at Old Trafford.
With the first leg ending in a goalless stalemate in Seville, United offered little invention at home as Wissam Ben Yedder's second-half brace sent Jose Mourinho's men out at the last-16 stage.
The Spaniards moved into the quarter-finals of the competition for the first time after Ben Yedder scored with a sharp turn and sweet shot past David De Gea in the 74th minute.
Four minutes later Ben Yedder doubled Sevilla's advantage with a header at the back post which the crossed the line after hitting the underside of the bar despite De Gea's efforts.
In Pictures | Champions League round of 16, second legs | 2017/18
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Romelu Lukaku pulled one back for Jose Mourinho's side in the 84th but there was to be no comeback for United, who drew 0-0 in the first leg, and the visitors could have added more.
Sevilla have never reached the Champions League quarter-finals but did make the European Cup quarter-finals in 1958.
Additional reporting by Reuters.