Diego Costa starts up front for Chelsea as Jose Mourinho's side look to get their first win of the season following last weekend's dissappointing draw at home to Swansea City.
In goal, summer signing Asmir Begovic replaces Thibaut Courtois with the Belgium international missing two matches through suspension following his red card against the Swans.
TEAMS IN FULL:
Manchester City starting XI: Hart, Sagna, Kompany, Mangala, Kolarov, Yaya Toure, Fernandinho, Navas, Silva, Sterling, Aguero
Substitutes: Caballero, Zabaleta, Clichy, Nasri, Demichelis, Bony, Iheanacho
Chelsea starting XI: Begovic; Ivanovic, Cahill, Terry, Azpilicueta; Ramires, Matic; Willian, Fabregas, Hazard; Diego Costa.
Substitutes: Blackman, Zouma, Mikel, Loftus-Cheek, Cuadrado, Falcao, Remy.
Mourinho: "We are speaking about 38 matches. It is an eternity, a marathon that started last week.
"I cannot say [this match] is not crucial, I cannot say it's not very, very, very important.
"They are title contenders so three points are important, but I cannot say that a win will mean anything significant."
Pellegrini: "I said the first day I arrived here I have my differences with him [Jose Mourinho] but I always shake hands with him.
"We are not thinking about the title in the second game but we are thinking about trying to win our points at home, especially as we are playing against the champions and one of the teams that has a lot of chances to win the title."
