England captain Chris Robshaw has been ruled out of the final Test against South Africa with a cracked right thumb.
Head coach Stuart Lancaster this afternoon confirmed the forward would take no further part in the series.
Hooker Dylan Hartley will take over as captain for Saturday's clash in Port Elizabeth.
Lancaster revealed that Robshaw had suffered a blow to the hand in the first Test in Durban before taking another knock in Saturday's second Test loss in Johannesburg.
Lancaster said: "Chris, as you would imagine, is devastated.
"He has led us superbly in the last seven internationals and been one of our standout performers.
"But the medical advice is that he should not play and we have to trust that expert opinion.
"Dylan Hartley will captain the side. He has been a key part of our leadership group and I know he will step up to the task on Saturday."
